Surface-Modified Melphalan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma | Zendy

Lee B. Sims | Zendy; Kevin M. Tyo | Zendy; Sanaya Stocke | Zendy; Mohamed Y. Mahmoud | Zendy; Aparna Ramasubramanian | Zendy; Jill M. Steinbach-Rankins | Zendy

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Surface-Modified Melphalan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma

Author(s) -

Lee B. Sims,

Kevin M. Tyo,

Sanaya Stocke,

Mohamed Y. Mahmoud,

Aparna Ramasubramanian,

Jill M. Steinbach-Rankins

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-26251

Subject(s) - melphalan , retinoblastoma , nanoparticle , materials science , methacrylate , emulsion , biomedical engineering , nanotechnology , chemistry , chemotherapy , medicine , copolymer , polymer , organic chemistry , composite material , surgery , biochemistry , gene

The goal of this work was to design and assess the ability of unmodified and surface-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) to enhance cell association, provide efficacy in retinoblastoma cells, and overcome current administration challenges, including hydrolysis and precipitation, of intravitreal administration.

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