Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury | Zendy

Wei Liu | Zendy; Fan Xia | Zendy; Yonju Ha | Zendy; Shuang Zhu | Zendy; Yi Li | Zendy; Oluwarotimi Folorunso | Zendy; Aryan Pashaei-Marandi | Zendy; Pei-Yi Lin | Zendy; Ronald G. Tilton | Zendy; Anson Pierce | Zendy; Hua Liu | Zendy; Wenbo Zhang | Zendy

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Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury

Author(s) -

Wei Liu,

Fan Xia,

Yonju Ha,

Shuang Zhu,

Yi Li,

Oluwarotimi Folorunso,

Aryan Pashaei-Marandi,

Pei-Yi Lin,

Ronald G. Tilton,

Anson Pierce,

Hua Liu,

Wenbo Zhang

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-26216

Subject(s) - hsf1 , neuroprotection , retinal , hsp70 , heat shock protein , heat shock factor , microbiology and biotechnology , biology , retina , ischemia , unfolded protein response , endoplasmic reticulum , medicine , pharmacology , neuroscience , biochemistry , gene

Retinal ischemia, a common cause of several vision-threatening diseases, contributes to the death of retinal neurons, particularly retinal ganglion cells (RGCs). Heat shock transcription factor 1 (HSF1), a stress-responsive protein, has been shown to be important in response to cellular stress stimuli, including ischemia. This study is to investigate whether HSF1 has a role in retinal neuronal injury in a mouse model of retinal ischemia-reperfusion (IR).

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