Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina | Zendy

Lara Carroll | Zendy; Hironori Uehara | Zendy; Daniel Fang | Zendy; Susie Choi | Zendy; Xiaohui Zhang | Zendy; Malkit Singh | Zendy; Zoya Sandhu | Zendy; Philip M. Cummins | Zendy; Tim M. Curtis | Zendy; Alan W. Stitt | Zendy; Bonnie Archer | Zendy; Balamurali K. Ambati | Zendy

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Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina

Author(s) -

Lara Carroll,

Hironori Uehara,

Daniel Fang,

Susie Choi,

Xiaohui Zhang,

Malkit Singh,

Zoya Sandhu,

Philip M. Cummins,

Tim M. Curtis,

Alan W. Stitt,

Bonnie Archer,

Balamurali K. Ambati

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-26182

Subject(s) - retinal , diabetic retinopathy , medicine , retina , ophthalmology , intravitreal administration , pathology , endocrinology , biology , diabetes mellitus , neuroscience

Deep retinal microvasculature of diabetic Ins2Akita eyes shows late stage changes consistent with disorganized vascular proliferation. We show that intravitreally injected AAV2.COMP-Ang1 blocks this increase in deep microvascularity, even when administered subsequent to development of the first detectable vascular defects. However, improving vascular normalization did not attenuate neuroretinal degeneration or loss of visual acuity. Therefore, additional interventions are required to address neurodegenerative changes that are already underway.

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