Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes | Zendy

Christi. Como | Zendy; Andrew N. Bubak | Zendy; Anna Blackmon | Zendy; Dallas Jones | Zendy; Niklaus H. Mueller | Zendy; Richard L. Davidson | Zendy; Maria A. Nagel | Zendy

Open Access

Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes

Author(s) -

Christi. Como,

Andrew N. Bubak,

Anna Blackmon,

Dallas Jones,

Niklaus H. Mueller,

Richard L. Davidson,

Maria A. Nagel

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-25801

Subject(s) - proinflammatory cytokine , biology , immunology , peripheral blood mononuclear cell , cytokine , immune system , virus , inflammation , virology , in vitro , biochemistry

While VZV DNA and antigen have been detected in acute and chronic VZV keratitis, it is unclear whether productive infection of corneal cells is ongoing or whether residual, noninfectious VZV antigens elicit inflammation. Herein, we examined VZV-infected primary human corneal epithelial cells (HCECs) and keratocytes (HKs) to elucidate the pathogenesis of VZV keratitis.

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