Distribution and Activity of Mitochondrial Proteins in Vascular and Avascular Retinas: Implications for Retinal Metabolism | Zendy

Glyn Chidlow | Zendy; John P. M. Wood | Zendy; Paul Ikgan Sia | Zendy; Robert J. Casson | Zendy

Open Access

Distribution and Activity of Mitochondrial Proteins in Vascular and Avascular Retinas: Implications for Retinal Metabolism

Author(s) -

Glyn Chidlow,

John P. M. Wood,

Paul Ikgan Sia,

Robert J. Casson

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-25536

Subject(s) - retinal , biology , retina , retinal pigment epithelium , mitochondrion , microbiology and biotechnology , biochemistry , neuroscience

Understanding the energetics of retinal neurons and glia is crucial for developing therapies for diseases that feature deficits in nutrient or oxygen availability. Herein, we performed a detailed characterization of the distribution and activity of mitochondrial proteins in the vascularized retinas of rat and marmoset, and the avascular retinas of rabbit and guinea pig. Further, we delineated expression of ubiquitous mitochondrial creatine kinase (uMtCK).

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