DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B | Zendy

Guangying Luo | Zendy; Jing Xia | Zendy; Shuai Yang | Zendy; Dewei Peng | Zendy; Jing Dong | Zendy; Li Li | Zendy; Peter S. Reinach | Zendy; Dongsheng Yan | Zendy

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DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B

Author(s) -

Guangying Luo,

Jing Xia,

Shuai Yang,

Dewei Peng,

Jing Dong,

Li Li,

Peter S. Reinach,

Dongsheng Yan

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-25443

Subject(s) - dna methylation , dnmt1 , biology , methylation , methyltransferase , bisulfite sequencing , dna methyltransferase , microbiology and biotechnology , epigenetics , cancer research , chemistry , gene expression , dna , gene , genetics

DNA methylation is a key epigenetic modification involved in various biological processes and diseases. Corneal epithelial wound healing (CEWH) is essential for restoring corneal integrity and transparency after injury. However, the role of DNA methylation in CEWH remains elusive. Here, we investigate the function and underlying mechanism of DNA methylation in regulating CEWH.

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