MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage | Zendy

Philippe M. D’Onofrio | Zendy; Alireza P. Shabanzadeh | Zendy; Brian Choi | Zendy; Mathias Bähr | Zendy; Paulo D. Koeberle | Zendy

Open Access

MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage

Author(s) -

Philippe M. D’Onofrio,

Alireza P. Shabanzadeh,

Brian Choi,

Mathias Bähr,

Paulo D. Koeberle

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-25257

Subject(s) - focal adhesion , optic nerve , integrin , microbiology and biotechnology , retinal ganglion cell , biology , extracellular matrix , chemistry , pathology , anatomy , medicine , signal transduction , cell , biochemistry

Integrin adherence to the extracellular matrix (ECM) is essential for retinal ganglion cell (RGC) survival: damage causes production and release of ECM degrading matrix metalloproteinases (MMPs) that disrupt integrin ligation, leading to RGC death. The interplay of MMPs, integrins, and focal adhesion kinase (FAK) was studied in RGCs after optic nerve injury.

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