Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration | Zendy

Wenyi Tang | Zendy; Jun Ma | Zendy; Ruiping Gu | Zendy; Boya Lei | Zendy; Xinyi Ding | Zendy; Gezhi Xu | Zendy

Open Access

Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration

Author(s) -

Wenyi Tang,

Jun Ma,

Ruiping Gu,

Boya Lei,

Xinyi Ding,

Gezhi Xu

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-25213

Subject(s) - gene knockdown , downregulation and upregulation , apoptosis , retinal , microbiology and biotechnology , retina , small hairpin rna , reactive oxygen species , tunel assay , biology , outer nuclear layer , retinal degeneration , programmed cell death , chemistry , biochemistry , neuroscience , gene

Lipocalin 2 (LCN2) is reported to be one of the key regulators of cell survival and death; however, its effect on retinal degeneration is unclear. Therefore, we aimed to investigate the role of LCN2 and its underlying mechanisms in light-induced retinal degeneration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research