Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts | Zendy

Kailin Chen | Zendy; Kairan Lai | Zendy; Xiaobo Zhang | Zendy; Zhenwei Qin | Zendy; Qiuli Fu | Zendy; Chenqi Luo | Zendy; Xiuming Jin | Zendy; Jianghua Hu | Zendy; Siyu Liu | Zendy; Ke Yao | Zendy

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Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

Author(s) -

Kailin Chen,

Kairan Lai,

Xiaobo Zhang,

Zhenwei Qin,

Qiuli Fu,

Chenqi Luo,

Xiuming Jin,

Jianghua Hu,

Siyu Liu,

Ke Yao

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-24743

Subject(s) - fibronectin , western blot , transforming growth factor , cell migration , wound healing , cell growth , chemistry , blot , trabecular meshwork , microbiology and biotechnology , cell , ciliary muscle , pharmacology , immunofluorescence , fibroblast , medicine , andrology , in vitro , immunology , endocrinology , biology , ophthalmology , biochemistry , glaucoma , antibody , accommodation , neuroscience , gene

Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown antifibrotic effects on several diseases. The aims of the present in vitro study were to investigate the antifibrotic effects of bromfenac (a kind of NSAID) on primary human pterygium fibroblasts (HPFs) and primary human conjunctival fibroblasts (HConFs), as well as to explore the possible mechanisms of these effects.

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