Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina | Zendy

Nilisha Fernando | Zendy; Yvette Wooff | Zendy; Riemke AggioBruce | Zendy; Joshua A. ChuTan | Zendy; Haihan Jiao | Zendy; Catherine Dietrich | Zendy; Matt Rutar | Zendy; Melissa Rooke | Zendy; Deepthi Me | Zendy; Janis T. Eells | Zendy; Krisztina Valter | Zendy; Philip G. Board | Zendy; Jan Provis | Zendy; Riccardo Natoli | Zendy

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Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina

Author(s) -

Nilisha Fernando,

Yvette Wooff,

Riemke AggioBruce,

Joshua A. ChuTan,

Haihan Jiao,

Catherine Dietrich,

Matt Rutar,

Melissa Rooke,

Deepthi Me,

Janis T. Eells,

Krisztina Valter,

Philip G. Board,

Jan Provis,

Riccardo Natoli

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-24627

Subject(s) - retina , ophthalmology , biology , optometry , medicine , neuroscience

Glutathione-S-transferase omega 1-1 (GSTO1-1) is a cytosolic glutathione transferase enzyme, involved in glutathionylation, toll-like receptor signaling, and calcium channel regulation. GSTO1-1 dysregulation has been implicated in oxidative stress and inflammation, and contributes to the pathogenesis of several diseases and neurological disorders; however, its role in retinal degenerations is unknown. The aim of this study was to investigate the role of GSTO1-1 in modulating oxidative stress and consequent inflammation in the normal and degenerating retina.

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