Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy | Zendy

Arul J. Duraisamy | Zendy; Manish Mishra | Zendy; Anjaneyulu Kowluru | Zendy; Renu A. Kowluru | Zendy

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Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy

Author(s) -

Arul J. Duraisamy,

Manish Mishra,

Anjaneyulu Kowluru,

Renu A. Kowluru

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-24548

Subject(s) - nadph oxidase , oxidative stress , rac1 , small interfering rna , biology , reactive oxygen species , chemistry , microbiology and biotechnology , endocrinology , biochemistry , transfection , signal transduction , gene

Oxidative stress plays a central role in the development of diabetic retinopathy, and in the pathogenesis of this blinding disease, activation of NADPH oxidase 2 (Nox2)-mediated cytosolic reactive oxygen species (ROS) production precedes mitochondrial damage. The multicomponent cytosolic Nox2 has an obligatory component, Ras-related C3 botulinum toxin substrate 1 (Rac1); in diabetes, Rac1 is functionally and transcriptionally active. Diabetes also facilitates many epigenetic modifications, and activates both DNA methylating (Dnmts) and hydroxymethylating (Tets) enzymes. Our aim was to investigate the role of epigenetics in Rac1 regulation in diabetes.

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