AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation | Zendy

Yonju Ha | Zendy; Wei Liu | Zendy; Hua Liu | Zendy; Shuang Zhu | Zendy; Fan Xia | Zendy; Julia E. Gerson | Zendy; Nisha A. Azhar | Zendy; Ronald G. Tilton | Zendy; Massoud Motamedi | Zendy; Rakez Kayed | Zendy; Wenbo Zhang | Zendy

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AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation

Author(s) -

Yonju Ha,

Wei Liu,

Hua Liu,

Shuang Zhu,

Fan Xia,

Julia E. Gerson,

Nisha A. Azhar,

Ronald G. Tilton,

Massoud Motamedi,

Rakez Kayed,

Wenbo Zhang

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-24427

Subject(s) - retinal ganglion cell , unfolded protein response , endoplasmic reticulum , optic nerve , programmed cell death , microbiology and biotechnology , chemistry , biology , neuroscience , biochemistry , apoptosis

Retinal ganglion cell (RGC) death following axonal injury occurring in traumatic optic neuropathy (TON) causes irreversible vision loss. GRP78 is a molecular chaperone that enhances protein folding and controls activation of endoplasmic reticulum (ER) stress pathways. This study determined whether adeno-associated virus (AAV)-mediated gene transfer of GRP78 protected RGCs from death in a mouse model of TON induced by optic nerve crush (ONC).

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