Lactic Acid Upregulates VEGF Expression in Macrophages and Facilitates Choroidal Neovascularization | Zendy

Juha Song | Zendy; Kihwang Lee | Zendy; Sung Wook Park | Zendy; Hyewon Chung | Zendy; Daun Jung | Zendy; Yi Rang Na | Zendy; Hailian Quan | Zendy; Chang Sik Cho | Zendy; Jeong-Hwan Che | Zendy; Jeong Hun Kim | Zendy; JaeHak Park | Zendy; Seung Hyeok Seok | Zendy

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Lactic Acid Upregulates VEGF Expression in Macrophages and Facilitates Choroidal Neovascularization

Author(s) -

Juha Song,

Kihwang Lee,

Sung Wook Park,

Hyewon Chung,

Daun Jung,

Yi Rang Na,

Hailian Quan,

Chang Sik Cho,

Jeong-Hwan Che,

Jeong Hun Kim,

JaeHak Park,

Seung Hyeok Seok

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-23892

Subject(s) - lactic acid , choroidal neovascularization , angiogenesis , neovascularization , umbilical vein , pathogenesis , microbiology and biotechnology , vascular endothelial growth factor a , macrophage , chemistry , vascular endothelial growth factor , biology , immunology , cancer research , biochemistry , in vitro , retinal , bacteria , vegf receptors , genetics

Lactic acid, the end product of glycolysis, has emerged as an immune-modulating metabolite in various diseases. In this study, we aimed to examine whether lactic acid contributes to the disease pathogenesis of choroidal neovascularization (CNV) and to investigate the role of macrophages in CNV pathogenesis.

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