Trichostatin A Ameliorates Conjunctival Fibrosis in a Rat Trabeculectomy Model | Zendy

Mi Sun Sung | Zendy; Gwang Hyeon Eom | Zendy; Soo Jin Kim | Zendy; So Young Kim | Zendy; Hwan Heo | Zendy; Sang Woo Park | Zendy

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Trichostatin A Ameliorates Conjunctival Fibrosis in a Rat Trabeculectomy Model

Author(s) -

Mi Sun Sung,

Gwang Hyeon Eom,

Soo Jin Kim,

So Young Kim,

Hwan Heo,

Sang Woo Park

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-23826

Subject(s) - trabeculectomy , trichostatin a , bleb (medicine) , fibrosis , masson's trichrome stain , myofibroblast , medicine , vascularity , wound healing , conjunctiva , histone deacetylase , pathology , glaucoma , chemistry , ophthalmology , surgery , histone , biochemistry , gene

To investigate whether histone deacetylase (HDAC) activity is associated with postoperative scarring and to evaluate the effect of HDAC inhibition by topical trichostatin A (TSA) on conjunctival fibrosis after trabeculectomy in a rat model.

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