Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury | Zendy

Hongdou Luo | Zendy; Jiejie Zhuang | Zendy; Piaopiao Hu | Zendy; Wei Ye | Zendy; Shanshan Chen | Zendy; Yulian Pang | Zendy; Ningfeng Li | Zendy; Cong Deng | Zendy; Xu Zhang | Zendy

Open Access

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

Author(s) -

Hongdou Luo,

Jiejie Zhuang,

Piaopiao Hu,

Wei Ye,

Shanshan Chen,

Yulian Pang,

Ningfeng Li,

Cong Deng,

Xu Zhang

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-23806

Subject(s) - gliosis , resveratrol , immunostaining , tunel assay , retina , retinal ganglion cell , retinal , glial fibrillary acidic protein , ganglion cell layer , electroretinography , ischemia , apoptosis , reperfusion injury , pathology , biology , pharmacology , medicine , immunohistochemistry , neuroscience , biochemistry

Resveratrol has been shown to enhance the survival of retinal ganglion cells (RGCs) following ischemia-reperfusion (I/R) injury for glaucoma. However, the precise mechanisms for resveratrol's protective effects are still unclear. The aim of this study is to determine whether resveratrol can inhibit RGC apoptosis, retinal gliosis, and inflammation, all of which are critical events in retinal degeneration following I/R injury.

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