Endothelial Protein C–Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells | Zendy

Anthoula Arta | Zendy; Anne Z. Eriksen | Zendy; Fredrik Melander | Zendy; Paul J. Kempen | Zendy; Michael Larsen | Zendy; Thomas L. Andresen | Zendy; Andrew J. Urquhart | Zendy

Open Access

Endothelial Protein C–Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells

Author(s) -

Anthoula Arta,

Anne Z. Eriksen,

Fredrik Melander,

Paul J. Kempen,

Michael Larsen,

Thomas L. Andresen,

Andrew J. Urquhart

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-23800

Subject(s) - liposome , flow cytometry , endothelial stem cell , pharmacology , nanocarriers , microbiology and biotechnology , chemistry , biology , medicine , in vitro , biochemistry , drug

To determine whether human retinal endothelial cells (HRECs) express the endothelial cell protein C receptor (EPCR) and to realize its potential as a targeting moiety by developing novel single and dual corticosteroid-loaded functionalized liposomes that exhibit both enhanced uptake by HRECs and superior biologic activity compared to nontargeting liposomes and free drug.

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