Antibodies to Conserved Surface Polysaccharides Protect Mice Against Bacterial Conjunctivitis | Zendy

Tanweer Zaidi | Zendy; Tauqeer Zaidi | Zendy; Gerald B. Pier | Zendy

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Antibodies to Conserved Surface Polysaccharides Protect Mice Against Bacterial Conjunctivitis

Author(s) -

Tanweer Zaidi,

Tauqeer Zaidi,

Gerald B. Pier

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-23795

Subject(s) - streptococcus pneumoniae , conjunctiva , microbiology and biotechnology , antibody , staphylococcus aureus , pseudomonas aeruginosa , immune system , monoclonal antibody , immunology , medicine , cornea , biology , bacteria , genetics , ophthalmology , antibiotics

Bacterial conjunctivitis is a major problem in ocular health. Little is known about protective immune effectors in the conjunctiva. We evaluated whether opsonic antibody to the conserved surface/capsular polysaccharide poly-N-acetyl glucosamine (PNAG) expressed by Streptococcus pneumoniae and Staphylococcus aureus was protective against bacterial conjunctivitis, as well as an antibody to the Pseudomonas aeruginosa surface polysaccharide alginate.

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