Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization | Zendy

Mingjun Tang | Zendy; Ying Yang | Zendy; Jingzhi Yu | Zendy; Jin Qiu | Zendy; Pei Chen | Zendy; YiHui Wu | Zendy; Qiyun Wang | Zendy; Zhuojun Xu | Zendy; Jian Ge | Zendy; Keming Yu | Zendy; Jing Zhuang | Zendy

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Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization

Author(s) -

Mingjun Tang,

Ying Yang,

Jingzhi Yu,

Jin Qiu,

Pei Chen,

YiHui Wu,

Qiyun Wang,

Zhuojun Xu,

Jian Ge,

Keming Yu,

Jing Zhuang

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-23712

Subject(s) - tetramethylpyrazine , chromatin immunoprecipitation , microbiology and biotechnology , corneal neovascularization , chemistry , neovascularization , western blot , cxcr4 , transcription factor , nf κb , biology , gene expression , chemokine , signal transduction , cancer research , receptor , medicine , pathology , angiogenesis , biochemistry , promoter , gene , alternative medicine

Tetramethylpyrazine (TMP) is the active ingredient extracted from the Chinese herb Chuanxiong. The purpose of our study was to identify the mechanism of therapeutic TMP suppression of pathologic chemokine receptor 4 (CXCR4) transcription.

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