A Disease-Associated MicroRNA Cluster Links Inflammatory Pathways and an Altered Composition of Leukocyte Subsets to Noninfectious Uveitis | Zendy

Fleurieke H. Verhagen | Zendy; Cornelis P. J. Bekker | Zendy; Marzia Rossato | Zendy; Sanne Hiddingh | Zendy; Lieuwe de Vries | Zendy; Abhinandan Devaprasad | Zendy; Aridaman Pandit | Zendy; Jeannette Ossewaarde–van Norel | Zendy; Ninette ten Dam | Zendy; Maartje C. A. Moret-Pot | Zendy; Saskia M. Imhof | Zendy; Joke H. de Boer | Zendy; Timothy R. D. J. Radstake | Zendy; Jonas J. W. Kuiper | Zendy

Open Access

A Disease-Associated MicroRNA Cluster Links Inflammatory Pathways and an Altered Composition of Leukocyte Subsets to Noninfectious Uveitis

Author(s) -

Fleurieke H. Verhagen,

Cornelis P. J. Bekker,

Marzia Rossato,

Sanne Hiddingh,

Lieuwe de Vries,

Abhinandan Devaprasad,

Aridaman Pandit,

Jeannette Ossewaarde–van Norel,

Ninette ten Dam,

Maartje C. A. Moret-Pot,

Saskia M. Imhof,

Joke H. de Boer,

Timothy R. D. J. Radstake,

Jonas J. W. Kuiper

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-23643

Subject(s) - microrna , biology , epigenetics , context (archaeology) , immunology , immune system , genetics , computational biology , gene , paleontology

The cause of noninfectious uveitis (NIU) is poorly understood but is considered to be mediated by a complex interplay between genetic, environmental, and-relatively unexplored-epigenetic factors. MicroRNAs (miRNAs) are noncoding small RNAs that are important epigenetic regulators implicated in pathologic signaling. Therefore, we mapped the circulating miRNA-ome of NIU patients and studied miRNA perturbations within the broader context of the immune system.

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