Self-Formation of RPE Spheroids Facilitates Enrichment and Expansion of hiPSC-Derived RPE Generated on Retinal Organoid Induction Platform | Zendy

Shengxu Liu | Zendy; Bing Xie | Zendy; Xiaojing Song | Zendy; Dandan Zheng | Zendy; Liwen He | Zendy; Guilan Li | Zendy; Guanjie Gao | Zendy; Fuhua Peng | Zendy; Minzhong Yu | Zendy; Jian Ge | Zendy; Xiufeng Zhong | Zendy

Open Access

Self-Formation of RPE Spheroids Facilitates Enrichment and Expansion of hiPSC-Derived RPE Generated on Retinal Organoid Induction Platform

Author(s) -

Shengxu Liu,

Bing Xie,

Xiaojing Song,

Dandan Zheng,

Liwen He,

Guilan Li,

Guanjie Gao,

Fuhua Peng,

Minzhong Yu,

Jian Ge,

Xiufeng Zhong

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-23613

Subject(s) - spheroid , organoid , retinal , retina , microbiology and biotechnology , retinal pigment epithelium , biology , cell culture , induced pluripotent stem cell , chemistry , anatomy , neuroscience , embryonic stem cell , biochemistry , genetics , gene

Retinal pigment epithelium (RPE) and neural retina could be generated concurrently through retinal organoid induction approaches using human induced pluripotent stem cells (hiPSCs), providing valuable sources for cell therapy of retinal degenerations. This study aims to enrich and expand hiPSC-RPE acquired with this platform and explore characteristics of serially passaged RPE cells.

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