The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation | Zendy

Ying Yuan | Zendy; Min Li | Zendy; Chi Ho To | Zendy; Thomas Chuen Lam | Zendy; Peng Wang | Zendy; Yunjie Yu | Zendy; Qingzhong Chen | Zendy; Xiaojun Hu | Zendy; Bilian Ke | Zendy

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The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation

Author(s) -

Ying Yuan,

Min Li,

Chi Ho To,

Thomas Chuen Lam,

Peng Wang,

Yunjie Yu,

Qingzhong Chen,

Xiaojun Hu,

Bilian Ke

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-23580

Subject(s) - rhoa , myofibroblast , rock2 , microbiology and biotechnology , calponin , rho associated protein kinase , blot , chemistry , sma* , actin , biology , kinase , signal transduction , pathology , biochemistry , medicine , gene , fibrosis , mathematics , combinatorics

Biomechanical properties changes and α-smooth muscle actin (α-SMA) overexpression are involved in myopia scleral remodeling. However, interactions between altered tissue biomechanics and cellular signaling that sustain scleral remodeling have not been well defined. We determine the mechanisms of mechanotransduction in the regulation of α-SMA expression during myopia scleral remodeling.

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