Proteomic Alterations in Aqueous Humor From Patients With Primary Open Angle Glaucoma | Zendy

Shruti Sharma | Zendy; Kathryn Bollinger | Zendy; Sai Karthik Kodeboyina | Zendy; Wenbo Zhi | Zendy; Jordan Patton | Zendy; Shan Bai | Zendy; Blake Edwards | Zendy; Lane Ulrich | Zendy; David Bogorad | Zendy; Ashok Sharma | Zendy

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Proteomic Alterations in Aqueous Humor From Patients With Primary Open Angle Glaucoma

Author(s) -

Shruti Sharma,

Kathryn Bollinger,

Sai Karthik Kodeboyina,

Wenbo Zhi,

Jordan Patton,

Shan Bai,

Blake Edwards,

Lane Ulrich,

David Bogorad,

Ashok Sharma

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-23434

Subject(s) - glaucoma , open angle glaucoma , fold change , pathogenesis , aqueous humor , ophthalmology , medicine , proteomics , chemistry , biology , biochemistry , downregulation and upregulation , gene

Primary open angle glaucoma (POAG) is the most prevalent form of glaucoma, accounting for approximately 90% of all cases. The aqueous humor (AH), a biological fluid in the anterior and posterior chambers of the eye, is involved in a multitude of functions including the maintenance of IOP and ocular homeostasis. This fluid is very close to the pathologic site and is also known to have a significant role in glaucoma pathogenesis. The purpose of this study was to identify proteomic alterations in AH from patients with POAG.

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