Cross-Inhibition of Norrin and TGF-β Signaling Modulates Development of Retinal and Choroidal Vasculature | Zendy

Roswitha Seitz | Zendy; Gregor R. Weber | Zendy; Sebastian Albrecht | Zendy; Rudolf Fuchshofer | Zendy; Ernst R. Tamm | Zendy; Andreas Ohlmann | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cross-Inhibition of Norrin and TGF-β Signaling Modulates Development of Retinal and Choroidal Vasculature

Author(s) -

Roswitha Seitz,

Gregor R. Weber,

Sebastian Albrecht,

Rudolf Fuchshofer,

Ernst R. Tamm,

Andreas Ohlmann

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-23403

Subject(s) - retinal , transforming growth factor , microbiology and biotechnology , neuroscience , chemistry , biology , ophthalmology , medicine

Norrin is essential for the formation of the retinal vasculature during development and promotes its repair after damage via activation of Wnt/β-catenin signaling. Since retinal TGF-β signaling has essentially opposite effects on the retinal vasculature we investigated if and how Norrin inhibits TGF-β signaling, and vice versa.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research