Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo | Zendy

Suneel Gupta | Zendy; Michael K Fink | Zendy; Arkasubhra Ghosh | Zendy; Ratnakar Tripathi | Zendy; Prashant R. Sinha | Zendy; Ajay Sharma | Zendy; Nathan P. Hesemann | Zendy; Shyam S. Chaurasia | Zendy; Elizabeth A. Giuliano | Zendy; Rajiv R. Mohan | Zendy

Open Access

Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo

Author(s) -

Suneel Gupta,

Michael K Fink,

Arkasubhra Ghosh,

Ratnakar Tripathi,

Prashant R. Sinha,

Ajay Sharma,

Nathan P. Hesemann,

Shyam S. Chaurasia,

Elizabeth A. Giuliano,

Rajiv R. Mohan

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-23308

Subject(s) - genetic enhancement , in vivo , hepatocyte growth factor , fibrosis , cornea , microbiology and biotechnology , chemistry , fibronectin , myofibroblast , pathology , medicine , ophthalmology , biology , gene , cell , biochemistry , receptor

We tested the potential of bone morphogenic protein 7 (BMP7) and hepatocyte growth factor (HGF) combination gene therapy to treat preformed corneal fibrosis using established rabbit in vivo and human in vitro models.

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