A Spatiotemporal Requirement for Prickle 1-Mediated PCP Signaling in Eyelid Morphogenesis and Homeostasis | Zendy

Dianlei Guo | Zendy; Zhaohui Yuan | Zendy; Jiali Ru | Zendy; Xinyu Gu | Zendy; Wang Zhang | Zendy; Fuxiang Mao | Zendy; Hong Ouyang | Zendy; Kaili Wu | Zendy; Yizhi Liu | Zendy; Chunqiao Liu | Zendy

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A Spatiotemporal Requirement for Prickle 1-Mediated PCP Signaling in Eyelid Morphogenesis and Homeostasis

Author(s) -

Dianlei Guo,

Zhaohui Yuan,

Jiali Ru,

Xinyu Gu,

Wang Zhang,

Fuxiang Mao,

Hong Ouyang,

Kaili Wu,

Yizhi Liu,

Chunqiao Liu

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22947

Subject(s) - eyelid , wnt signaling pathway , biology , microbiology and biotechnology , morphogenesis , embryonic stem cell , downregulation and upregulation , mutant , signal transduction , genetics , medicine , surgery , gene

Tissue closure/fusion is a fundamental process during organogenesis, driven in part by the Wnt/planar cell polarity (Wnt/PCP) pathway. This study explored the spatial and temporal aspects of PCP signaling in eyelid development through analysis of mice lacking Prickle 1, a core PCP component, and the Prickle1-dependent signaling networks underlying eyelid development.

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