Integrin-Linked Kinase Controls Choroidal Neovascularization by Recruitment of Endothelial Progenitor Cells | Zendy

Xiumei Yang | Zendy; Chunguang Duan | Zendy; Jian Zhang | Zendy; Xiao-jie Qu | Zendy; Yusheng Wang | Zendy

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Integrin-Linked Kinase Controls Choroidal Neovascularization by Recruitment of Endothelial Progenitor Cells

Author(s) -

Xiumei Yang,

Chunguang Duan,

Jian Zhang,

Xiao-jie Qu,

Yusheng Wang

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22931

Subject(s) - integrin linked kinase , protein kinase b , vascular endothelial growth factor , vasculogenesis , microbiology and biotechnology , choroidal neovascularization , endothelial progenitor cell , progenitor cell , cancer research , angiogenesis , gene silencing , vascular endothelial growth factor a , neovascularization , retinal pigment epithelium , mapk/erk pathway , kinase , biology , chemistry , phosphorylation , protein kinase a , stem cell , retinal , retina , cyclin dependent kinase 2 , neuroscience , biochemistry , gene , vegf receptors

Vasculogenesis has been shown to contribute to the formation of choroidal neovascularization (CNV). However, the mechanism behind the recruitment of endothelial progenitor cells (EPC) to CNV is not well understood. Therefore, we were interested to know whether integrin-linked kinase (ILK) plays a role in recruiting EPC to CNV, and its possible mechanism.

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