Photodynamic Therapy Leads to Time-Dependent Regression of Pathologic Corneal (Lymph) Angiogenesis and Promotes High-Risk Corneal Allograft Survival | Zendy

Yanhong Hou | Zendy; Viet Nhat Hung Le | Zendy; Thomas Clahsen | Zendy; Ann-Charlott Schneider | Zendy; Felix Bock | Zendy; Claus Cursiefen | Zendy

Open Access

Photodynamic Therapy Leads to Time-Dependent Regression of Pathologic Corneal (Lymph) Angiogenesis and Promotes High-Risk Corneal Allograft Survival

Author(s) -

Yanhong Hou,

Viet Nhat Hung Le,

Thomas Clahsen,

Ann-Charlott Schneider,

Felix Bock,

Claus Cursiefen

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22904

Subject(s) - verteporfin , lymphangiogenesis , medicine , photodynamic therapy , lymphatic vessel , corneal neovascularization , lymphatic system , blood vessel , neovascularization , cornea , corneal transplantation , surgery , transplantation , angiogenesis , ophthalmology , pathology , cancer , choroidal neovascularization , macular degeneration , metastasis , chemistry , organic chemistry

Pathologic corneal (lymph) angiogenesis is a known risk factor for immune-mediated allograft rejections after corneal transplantation. However, there is no established treatment to regress pre-existing pathological corneal blood and lymphatic vessels. This study assessed the possibility to regress both vessel types by photodynamic therapy (PDT) after intravenous (i.v.) verteporfin injection, the influence of timing of PDT after verteporfin injection, and the effect on graft survival in high-risk keratoplasty.

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