Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration | Zendy

Jingtai Cao | Zendy; Thomas MacPherson | Zendy; Bibiana V. Iglesias | Zendy; Yang Liu | Zendy; Natasha Tirko | Zendy; George D. Yancopoulos | Zendy; Stanley J. Wiegand | Zendy; Carmelo Romano | Zendy

Open Access

Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration

Author(s) -

Jingtai Cao,

Thomas MacPherson,

Bibiana V. Iglesias,

Yang Liu,

Natasha Tirko,

George D. Yancopoulos,

Stanley J. Wiegand,

Carmelo Romano

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22897

Subject(s) - aflibercept , medicine , retinal , ophthalmology , clearance , pharmacology , surgery , bevacizumab , chemotherapy , urology

We establish and characterize the chronic retinal neovascularization (RNV) induced by intravitreal (IVT) injection of DL-α-aminoadipic acid (AAA) in a rabbit model and investigate the extent and duration of inhibitory actions induced by IVT aflibercept on the RNV.

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