Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models | Zendy

Maura Crowley | Zendy; Omar Delgado | Zendy; Adrian Will-Orrego | Zendy; Natasha Buchanan | Zendy; Karen Anderson | Zendy; Bruce Jaffee | Zendy; Thaddeus P. Dryja | Zendy; Sha-Mei Liao | Zendy

Open Access

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

Author(s) -

Maura Crowley,

Omar Delgado,

Adrian Will-Orrego,

Natasha Buchanan,

Karen Anderson,

Bruce Jaffee,

Thaddeus P. Dryja,

Sha-Mei Liao

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22605

Subject(s) - complement system , factor h , complement factor b , lipopolysaccharide , tlr4 , alternative complement pathway , complement factor i , complement component 2 , complement component 5 , medicine , immunology , complement component 3 , antibody , complement membrane attack complex , complement control protein , receptor , inflammation

Genome-wide association studies suggest a role for the complement system in age-related macular degeneration (AMD). We characterized ocular complement activation and evaluated a complement factor D (FD) neutralizing antibody.

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