Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis | Zendy

Heather Clark | Zendy; Martin Minns | Zendy; Yan Sun | Zendy; Tristan de Jesus | Zendy; Mahmoud Ghannoum | Zendy; Eric Pearlman | Zendy

Open Access

Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis

Author(s) -

Heather Clark,

Martin Minns,

Yan Sun,

Tristan de Jesus,

Mahmoud Ghannoum,

Eric Pearlman

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22585

Subject(s) - atovaquone , microbiology and biotechnology , fungal keratitis , biology , aspergillus , fusarium , in vivo , keratitis , hypha , botany , immunology , plasmodium falciparum , genetics , malaria

Aspergillus and Fusarium molds cause blinding corneal infections as a consequence of ocular trauma and in association with contact lens wear. As these fungi require zinc for fungal growth, we examined the effect of atovaquone, a ubiquinone analog that disrupts zinc homeostasis, on fungal growth in vitro and in vivo.

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