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The clearer divergence in spectral sensitivity between native rod and human L-cone (L*-cone) opsins in the transgenic Opn1lwLIAIS mouse (LIAIS) allows normal visual processes mediated by these photoreceptor subtypes to be isolated effectively using the silent substitution technique. The objective of this study was to further characterize the influence of mean luminance and temporal frequency on the functional properties of signals originating in each photoreceptor separately and independently of adaptation state in LIAIS mice.

Mesopic and Photopic Rod and Cone Photoreceptor-Driven Visual Processes in Mice With Long-Wavelength–Shifted Cone Pigments