Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy | Zendy

Jeanette Eresch | Zendy; Martin Stumpf | Zendy; Alexander Koch | Zendy; Rajkumar Vutukuri | Zendy; Nerea Ferreirós | Zendy; Yannick Schreiber | Zendy; Katrin Schröder | Zendy; Kavi Devraj | Zendy; Rüdiger Popp | Zendy; Andrea Huwiler | Zendy; LarsOlof Hattenbach | Zendy; Josef Pfeilschifter | Zendy; Waltraud Pfeilschifter | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy

Author(s) -

Jeanette Eresch,

Martin Stumpf,

Alexander Koch,

Rajkumar Vutukuri,

Nerea Ferreirós,

Yannick Schreiber,

Katrin Schröder,

Kavi Devraj,

Rüdiger Popp,

Andrea Huwiler,

LarsOlof Hattenbach,

Josef Pfeilschifter,

Waltraud Pfeilschifter

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22544

Subject(s) - angiogenesis , neovascularization , vascular endothelial growth factor a , sphingosine , vascular endothelial growth factor , retinal , cancer research , microbiology and biotechnology , biology , biochemistry , receptor , vegf receptors

Neovascularization is a major cause of blindness in various ocular diseases. Bioactive sphingosine 1-phosphate (S1P), synthesized by two sphingosine kinases (Sphk1, Sphk2), emerged as a key player in a multitude of cellular processes, including cell survival, proliferation, inflammation, migration, and angiogenesis. We investigated the role of Sphk2, S1P, and S1P receptors (S1PR) during retinal neovascularization using the oxygen-induced retinopathy mouse model (OIR).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research