Ghrelin Attenuates Retinal Neuronal Autophagy and Apoptosis in an Experimental Rat Glaucoma Model | Zendy

Ke Zhu | Zendy; Menglu Zhang | Zendy; Shuting Liu | Zendy; Xueyan Li | Zendy; ShuMin Zhong | Zendy; Fang Li | Zendy; Gezhi Xu | Zendy; Zhongfeng Wang | Zendy; Yanying Miao | Zendy

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Ghrelin Attenuates Retinal Neuronal Autophagy and Apoptosis in an Experimental Rat Glaucoma Model

Author(s) -

Ke Zhu,

Menglu Zhang,

Shuting Liu,

Xueyan Li,

ShuMin Zhong,

Fang Li,

Gezhi Xu,

Zhongfeng Wang,

Yanying Miao

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22465

Subject(s) - autophagy , ghrelin , glaucoma , apoptosis , retinal , rat model , endocrinology , medicine , chemistry , neuroscience , ophthalmology , biology , hormone , biochemistry

Ghrelin, a natural ligand for the growth hormone secretagogue receptor type 1a (GHSR-1a), may protect retinal neurons against glaucomatous injury. We therefore characterized the underlying mechanism of the ghrelin/GHSR-1a-mediated neuroprotection with a rat chronic intraocular hypertension (COH) model.

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