Systemic Biodistribution and Intravitreal Pharmacokinetic Properties of Bevacizumab, Ranibizumab, and Aflibercept in a Nonhuman Primate Model | Zendy

John Christoforidis | Zendy; Karen Briley | Zendy; Katherine Binzel | Zendy; Prayna Bhatia | Zendy; Lai Wei | Zendy; Krishan Kumar | Zendy; Michael V. Knopp | Zendy

Open Access

Systemic Biodistribution and Intravitreal Pharmacokinetic Properties of Bevacizumab, Ranibizumab, and Aflibercept in a Nonhuman Primate Model

Author(s) -

John Christoforidis,

Karen Briley,

Katherine Binzel,

Prayna Bhatia,

Lai Wei,

Krishan Kumar,

Michael V. Knopp

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22431

Subject(s) - ranibizumab , bevacizumab , aflibercept , medicine , biodistribution , pharmacokinetics , ophthalmology , macular degeneration , pharmacology , chemotherapy , chemistry , biochemistry , in vitro

To determine the intravitreal pharmacokinetic properties and to study the systemic biodistribution characteristics of I-124-labeled bevacizumab, ranibizumab, and aflibercept with positron emission tomography-computed tomography (PET/CT) imaging in a nonhuman primate model.

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