Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells | Zendy

Baiyun Liu | Zendy; Jason I. Kilpatrick | Zendy; Bartłomiej Łukasz | Zendy; Suzanne Jarvis | Zendy; Fiona McDonnell | Zendy; Deborah Wallace | Zendy; Abbot F. Clark | Zendy; Colm O’Brien | Zendy

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Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells

Author(s) -

Baiyun Liu,

Jason I. Kilpatrick,

Bartłomiej Łukasz,

Suzanne Jarvis,

Fiona McDonnell,

Deborah Wallace,

Abbot F. Clark,

Colm O’Brien

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22400

Subject(s) - myofibroblast , vinculin , extracellular matrix , focal adhesion , microbiology and biotechnology , trabecular meshwork , chemistry , actin , glaucoma , fibrosis , cell , pathology , biology , medicine , ophthalmology , biochemistry

Alteration in the extracellular matrix (ECM) of the optic nerve head (ONH) causes lamina cribrosa (LC) fibrosis and affects the mechanical integrity of the ONH. Increased ECM tissue stiffness drives myofibroblast activation leading to tissue fibrosis throughout the body. Here using primary human LC cells, we investigate the effect of substrate stiffness on profibrotic changes, which might be a key molecular mechanism driving ECM remodeling of the LC in primary open-angle glaucoma (POAG) glaucoma.

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