Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics | Zendy

Rachel Doherty | Zendy; Karen Sisley | Zendy; David W. Hammond | Zendy; I G Rennie | Zendy; Neil A. Cross | Zendy

Open Access

Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics

Author(s) -

Rachel Doherty,

Karen Sisley,

David W. Hammond,

I G Rennie,

Neil A. Cross

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22272

Subject(s) - cd44 , cancer stem cell , phenotype , biology , cancer research , stem cell , phenotypic plasticity , melanoma , aldehyde dehydrogenase , stem cell marker , metastasis , neural crest , tumor progression , cancer , cell , microbiology and biotechnology , genetics , gene , embryo

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and approximately half of those diagnosed will die of metastasis. This study investigates whether UM progression is driven by a subpopulation of stem-like cells, termed "cancer stem cells" (CSCs).

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