The Effect of Denatured Lysozyme on Human Corneal Epithelial Cells | Zendy

David J. McCanna | Zendy; Sarah Soyeon Oh | Zendy; Junghee Seo | Zendy; Chantal Coles-Brennan | Zendy; Zohra Fadli | Zendy; Lakshman N. Subbaraman | Zendy; Lyndon Jones | Zendy

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The Effect of Denatured Lysozyme on Human Corneal Epithelial Cells

Author(s) -

David J. McCanna,

Sarah Soyeon Oh,

Junghee Seo,

Chantal Coles-Brennan,

Zohra Fadli,

Lakshman N. Subbaraman,

Lyndon Jones

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22260

Subject(s) - lysozyme , confocal microscopy , chemistry , viability assay , contact lens , biophysics , biochemistry , cell , microbiology and biotechnology , biology , medicine , ophthalmology

During contact lens wear, the amount of lysozyme deposited on contact lenses varies depending on the lens material. The binding of lysozyme to some contact lens materials may result in a conformational change that denatures the protein to an inactive form. This investigation evaluated the effect that denatured lysozyme has on human corneal epithelial cells (HCECs) by measuring cell viability and the release of inflammatory cytokines.

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