Micro- and Nanoscale Topographies on Silk Regulate Gene Expression of Human Corneal Epithelial Cells | Zendy

Kai B. Kang | Zendy; Brian D. Lawrence | Zendy; Xiaoyi Gao | Zendy; Yuncin Luo | Zendy; Qiang Zhou | Zendy; Aihong Liu | Zendy; Victor H. Guaiquil | Zendy; Mark I. Rosenblatt | Zendy

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Micro- and Nanoscale Topographies on Silk Regulate Gene Expression of Human Corneal Epithelial Cells

Author(s) -

Kai B. Kang,

Brian D. Lawrence,

Xiaoyi Gao,

Yuncin Luo,

Qiang Zhou,

Aihong Liu,

Victor H. Guaiquil,

Mark I. Rosenblatt

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22213

Subject(s) - microbiology and biotechnology , focal adhesion , cytoskeleton , vinculin , biology , gene expression , cell adhesion , corneal epithelium , actin cytoskeleton , cell , signal transduction , gene , epithelium , genetics

Corneal basement membrane has topographical features that provide biophysical cues to direct cell adherence, migration, and proliferation. In this study, we hypothesize that varying topographic pitch created on silk films can alter epithelial cell morphology, adhesion, and the genetic expression involved in cytoskeletal dynamics-related pathways.

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