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Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa
Author(s) -
Ke Wang,
Bo Peng,
Jia Xiao,
Orly Weinreb,
Moussa B. H. Youdim,
Bin Lin
Publication year - 2017
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.17-22096
Subject(s) - retinitis pigmentosa , programmed cell death , retinal degeneration , photoreceptor cell , neuroprotection , retinal , retina , oxidative stress , apoptosis , medicine , pharmacology , biology , ophthalmology , biochemistry , neuroscience
Retinitis pigmentosa (RP) is a group of hereditary retinal degeneration in which mutations commonly result in the initial phase of rod cell death followed by gradual cone cell death. The mechanisms by which the mutations lead to photoreceptor cell death in RP have not been clearly elucidated. There is currently no effective treatment for RP. The purpose of this work was to explore iron chelation therapy for improving cone survival and function in the rd10 mouse model of RP.

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