Axonal Protection by Ripasudil, a Rho Kinase Inhibitor, via Modulating Autophagy in TNF-Induced Optic Nerve Degeneration | Zendy

Yasushi Kitaoka | Zendy; Kana Sase | Zendy; Chihiro Tsukahara | Zendy; Kaori Kojima | Zendy; Akira Shiono | Zendy; Jiro Kogo | Zendy; Naoto Tokuda | Zendy; Hitoshi Takagi | Zendy

Open Access

Axonal Protection by Ripasudil, a Rho Kinase Inhibitor, via Modulating Autophagy in TNF-Induced Optic Nerve Degeneration

Author(s) -

Yasushi Kitaoka,

Kana Sase,

Chihiro Tsukahara,

Kaori Kojima,

Akira Shiono,

Jiro Kogo,

Naoto Tokuda,

Hitoshi Takagi

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-22000

Subject(s) - axon , optic nerve , autophagy , chemistry , downregulation and upregulation , microbiology and biotechnology , pharmacology , anatomy , biology , apoptosis , biochemistry , gene

The Rho kinase inhibitor ripasudil decreases intraocular pressure, although its role in optic nerve axonal damage should be clarified. We therefore investigated whether ripasudil modulates TNF-induced axonal loss and affects autophagy machinery after the induction of optic nerve degeneration.

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