The Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure | Zendy

Hannah C. Webber | Zendy; Jaclyn Y. Bermudez | Zendy; J. Cameron Millar | Zendy; Weiming Mao | Zendy; Abbot F. Clark | Zendy

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The Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure

Author(s) -

Hannah C. Webber,

Jaclyn Y. Bermudez,

J. Cameron Millar,

Weiming Mao,

Abbot F. Clark

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21964

Subject(s) - wnt signaling pathway , wnt3a , cadherin , paracellular transport , microbiology and biotechnology , chemistry , transcellular , trabecular meshwork , catenin , cell , signal transduction , biology , medicine , intraocular pressure , ophthalmology , membrane , biochemistry , permeability (electromagnetism)

Wnt/β-catenin signaling in the trabecular meshwork (TM) is required for maintaining normal intraocular pressure (IOP), although the mechanism(s) behind this are unknown. We hypothesize that Wnt/β-catenin signaling regulates IOP via β-catenin's effects on cadherin junctions.

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