Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa | Zendy

Jing Wang | Zendy; Alan Saul | Zendy; Xuezhi Cui | Zendy; Penny Roon | Zendy; Sylvia B. Smith | Zendy

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Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa

Author(s) -

Jing Wang,

Alan Saul,

Xuezhi Cui,

Penny Roon,

Sylvia B. Smith

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21947

Subject(s) - retinitis pigmentosa , photoreceptor cell , retinal degeneration , retinal , retina , biology , outer nuclear layer , electroretinography , anatomy , neuroscience , biochemistry

Sigma 1 Receptor (Sig1R) is a novel therapeutic target in neurodegenerative diseases, including retinal disease. Sig1R-/- mice have late-onset retinal degeneration with ganglion cell loss that worsens under stress. Whether Sig1R plays a role in maintaining other retinal neurons is unknown, but was investigated here using rd10 mice, a model of severe photoreceptor degeneration.

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