Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells | Zendy

Jason Charng | Zendy; Samuel G. Jacobson | Zendy; Elise Héon | Zendy; Alejandro J. Román | Zendy; David B. McGuigan | Zendy; Rebecca Sheplock | Zendy; Mychajlo S. Kosyk | Zendy; Małgorzata Świder | Zendy; Artur V. Cideciyan | Zendy

Open Access

Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells

Author(s) -

Jason Charng,

Samuel G. Jacobson,

Elise Héon,

Alejandro J. Román,

David B. McGuigan,

Rebecca Sheplock,

Mychajlo S. Kosyk,

Małgorzata Świder,

Artur V. Cideciyan

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21909

Subject(s) - pupillary light reflex , retina , electroretinography , stimulus (psychology) , retinal , ophthalmology , pupillary reflex , reflex , pupillometry , ganglion , neuroscience , biology , audiology , pupil , medicine , psychology , psychotherapist

Pupillary light reflex (PLR) is driven by outer retinal photoreceptors and by melanopsin-expressing intrinsically photosensitive retinal ganglion cells of the inner retina. To isolate the melanopic component, we studied patients with severe vision loss due to Leber congenital amaurosis (LCA) caused by gene mutations acting on the outer retina.

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