Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma | Zendy

Simone L. Scholz | Zendy; Inga Möller | Zendy; Henning Reis | Zendy; Daniela Süßkind | Zendy; Johannes A.P. van de Nes | Zendy; Sonia Leonardelli | Zendy; Bastian Schilling | Zendy; Elisabeth Livingstone | Zendy; Tobias Schimming | Zendy; Annette Paschen | Zendy; Antje Sucker | Zendy; Rajmohan Murali | Zendy; KlausPeter Steuhl | Zendy; Dirk Schadendorf | Zendy; Henrike Westekemper | Zendy; Klaus Griewank | Zendy

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Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma

Author(s) -

Simone L. Scholz,

Inga Möller,

Henning Reis,

Daniela Süßkind,

Johannes A.P. van de Nes,

Sonia Leonardelli,

Bastian Schilling,

Elisabeth Livingstone,

Tobias Schimming,

Annette Paschen,

Antje Sucker,

Rajmohan Murali,

KlausPeter Steuhl,

Dirk Schadendorf,

Henrike Westekemper,

Klaus Griewank

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21838

Subject(s) - gnaq , ciliary body , iris (biosensor) , melanoma , medicine , bap1 , uvea , mutation , cancer research , ophthalmology , biology , genetics , gene , computer security , computer science , biometrics

The most common malignant intraocular tumors with a high mortality in adults are uveal melanomas. Uveal melanomas arise most frequently in the choroid or ciliary body (97%) and rarely in the iris (3%). Whereas conjunctival and posterior uveal (ciliary body and choroidal) melanomas have been studied in more detail genetically, little data exist regarding iris melanomas.

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