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Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns
Author(s) -
Romain Joubert,
Estelle Daniel,
Nicolas Bonnin,
Aurélie Comptour,
Christelle Gross,
Corinne Belville,
Frédéric Chiambaretta,
Loı̈c Blanchon,
Vincent Sapin
Publication year - 2017
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.17-21810
Subject(s) - retinoic acid , wound healing , amnion , saline , matrix metalloproteinase , medicine , chemical burn , vascular endothelial growth factor , tretinoin , andrology , retinoic acid receptor , pharmacology , chemistry , surgery , biochemistry , vegf receptors , biology , fetus , pregnancy , genetics , gene
Alkali burns are the most common, severe chemical ocular injuries, their functional prognosis depending on corneal wound healing efficiency. The purpose of our study was to compare the benefits of amniotic membrane (AM) grafts and homogenates for wound healing in the presence or absence of previous all-trans retinoic acid (atRA) treatment.

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