The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy | Zendy

Rustum Karanjia | Zendy; Adriana Berezovsky | Zendy; Paula Yuri Sacai | Zendy; Nívea Nunes Cavascan | Zendy; Henry Yuheng Liu | Zendy; Samir Nazarali | Zendy; Milton N. Moraes-Filho | Zendy; Kirsten Anderson | Zendy; Jeffrey Tran | Zendy; Sung EunSong Watanabe | Zendy; Milton Moraes | Zendy; Federico Sadun | Zendy; Anna Maria DeNegri | Zendy; Piero Barboni | Zendy; Carolina do Val Ferreira Ramos | Zendy; Chiara La Morgia | Zendy; Valério Carelli | Zendy; Rubens Belfort | Zendy; Stuart G. Coupland | Zendy; Solange Rios Salomão | Zendy; Alfredo A. Sadun | Zendy

Open Access

The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy

Author(s) -

Rustum Karanjia,

Adriana Berezovsky,

Paula Yuri Sacai,

Nívea Nunes Cavascan,

Henry Yuheng Liu,

Samir Nazarali,

Milton N. Moraes-Filho,

Kirsten Anderson,

Jeffrey Tran,

Sung EunSong Watanabe,

Milton Moraes,

Federico Sadun,

Anna Maria DeNegri,

Piero Barboni,

Carolina do Val Ferreira Ramos,

Chiara La Morgia,

Valério Carelli,

Rubens Belfort,

Stuart G. Coupland,

Solange Rios Salomão,

Alfredo A. Sadun

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21773

Subject(s) - photopic vision , ophthalmology , medicine , optic neuropathy , erg , electroretinography , leber's hereditary optic neuropathy , retinal , optic nerve

The photopic negative response (PhNR) is a slow negative component of a flash photopic full-field ERG that has been shown to be specific for retinal ganglion cell (RGC) activity. Direct evaluation of RGC function is desirable in patients with Leber's hereditary optic neuropathy (LHON) in which the loss of central acuity can make it difficult to monitor patients with standard metrics. The purpose of this study was to evaluate the use of PhNR as an objective noninvasive clinical metric in LHON.

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