Xeno-Free Cultivation of Mesenchymal Stem Cells From the Corneal Stroma | Zendy

Steffi Matthyssen | Zendy; Sorcha Ní Dhubhghaill | Zendy; Veerle Van Gerwen | Zendy; Nadia Zakaria | Zendy

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Xeno-Free Cultivation of Mesenchymal Stem Cells From the Corneal Stroma

Author(s) -

Steffi Matthyssen,

Sorcha Ní Dhubhghaill,

Veerle Van Gerwen,

Nadia Zakaria

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21676

Subject(s) - mesenchymal stem cell , fetal bovine serum , cd34 , andrology , cd90 , stem cell , stromal cell , immunology , biology , chemistry , in vitro , microbiology and biotechnology , medicine , biochemistry , cancer research

The human cornea has recently been described as a source of corneal stroma-derived mesenchymal stem cells (hMSCs). In vitro expansion of these cells involves basal medium supplemented with fetal bovine serum (FBS). As animal-derived serum can confer a risk of disease transmission and can be subject to considerable lot-to-lot variability, it does not comply with newer Good Manufacturing Practice (GMP)-required animal component-free culture protocols for clinical translation.

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