Differential Effects of HCN Channel Block on On and Off Pathways in the Retina as a Potential Cause for Medication-Induced Phosphene Perception | Zendy

Sebastian Bemme | Zendy; Michael Weick | Zendy; Tim Gollisch | Zendy

Open Access

Differential Effects of HCN Channel Block on On and Off Pathways in the Retina as a Potential Cause for Medication-Induced Phosphene Perception

Author(s) -

Sebastian Bemme,

Michael Weick,

Tim Gollisch

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21572

Subject(s) - phosphene , retina , ivabradine , hcn channel , stimulation , neuroscience , visual phototransduction , biophysics , chemistry , retinal , biology , medicine , ion channel , receptor , heart rate , biochemistry , transcranial magnetic stimulation , blood pressure

Phosphene perception is a characteristic side effect of heart rate-reducing medication that acts on hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels. It is hypothesized that these phosphenes are caused by blocking HCN channels in photoreceptors and neurons of the retina, yet the underlying changes in visual signal processing in the retina caused by the HCN channel block are still unknown.

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