The Ocular Glymphatic System and Idiopathic Intracranial Hypertension: Author Response to “Hypodense Holes and the Ocular Glymphatic System”

The proposal that there exists a paravascular transport system within the eye, similar and likely continuous with the glymphatic system in the central nervous system (CNS), is an exciting development with implications to the pathogenesis of a number of common ocular diseases, and one that may open up new targets for treatment. We are delighted to see in this most recent correspondence how Wostyn and colleagues present further evidence to support the existence of such a system in the optic nerve and its potential relevance to the pathogenesis of glaucoma. Building on our initial hypothesis reported in Investigative Ophthalmology & Visual Science, we have now made important progress in identifying its relevance to another sight-threatening condition with a fluiddynamic component, idiopathic intracranial hypertension (IIH). We believe that these observations corroborate the most recent findings of Wostyn and colleagues, and provide