Fingolimod Suppresses a Cascade of Core Vicious Cycle in Dry Eye NOD Mouse Model: Involvement of Sphingosine-1-Phosphate Receptors in Infiltrating Leukocytes | Zendy

Weibao Xiao | Zendy; Shuhao Fu | Zendy; Kang Xu | Zendy; Ronghua Feng | Zendy; Fei Sun | Zendy; Wen Ye | Zendy

Open Access

Fingolimod Suppresses a Cascade of Core Vicious Cycle in Dry Eye NOD Mouse Model: Involvement of Sphingosine-1-Phosphate Receptors in Infiltrating Leukocytes

Author(s) -

Weibao Xiao,

Shuhao Fu,

Kang Xu,

Ronghua Feng,

Fei Sun,

Wen Ye

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.17-21445

Subject(s) - nod , fingolimod , sphingosine 1 phosphate , receptor , sphingosine 1 phosphate receptor , sphingosine , medicine , pharmacology , chemistry , immunology , endocrinology , multiple sclerosis , diabetes mellitus

The purpose of this study was to evaluate the inhibitory mechanism of fingolimod and the involvement of sphingosine-1-phosphate receptors (S1PRs) and cytokines-matrix metalloproteinases (MMPs)/MAP kinases (MAPKs) signaling in a dry eye disease (DED) mouse model.

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